Key Points Type I IFN–mediated JAK–STAT signaling is impaired in Perforin-2–deficient cells. Perforin-2 independently associates with IFNAR1 and IFNAR2 in resting cells. Perforin-2 is critical for the activation of Jak1...
Learn moreLeukemia Inhibitory Factor Inhibits Plasmacytoid Dendritic Cell Function and Development [INNATE IMMUNITY AND INFLAMMATION]
Key Points pDCs express LIFR. LIF inhibits pDC production of type I IFN. LIF biases DC development towards cDCs at the expense of pDCs...
Learn moreNegative Regulation of TLR Signaling by BCAP Requires Dimerization of Its DBB Domain [MOLECULAR AND STRUCTURAL IMMUNOLOGY]
Key Points Dimerization of the BCAP Toll/IL1 domain is required for function. BCAP TIR modulates the oligomerization state of TLR signaling adaptor MAL. TIG domains are a promiscuous dimerization module in gene expression and signaling...
Learn moreGut Microbiota Contributes to Spontaneous Colitis in E3 Ligase Itch-Deficient Mice [MUCOSAL IMMUNOLOGY]
Key Points Spontaneous colitis in Itch-deficient mice is associated with altered gut microbiota. Alterations in gut microbiota are independent of elevated IL-17 in Itch-deficient mice. Bacteroides vulgatus induces colonic inflammation in...
Learn moreNeutrophil Extracellular Trap-Associated CEACAM1 as a Putative Therapeutic Target to Prevent Metastatic Progression of Colon Carcinoma [TUMOR IMMUNOLOGY]
Key Points CEACAM1 is an essential contributor in the NET–tumor cell interaction. CEACAM1 is a potential target for preventing liver metastasis of colon cancer...
Learn moreCancer Cell-Intrinsic Expression of MHC Class II Regulates the Immune Microenvironment and Response to Anti-PD-1 Therapy in Lung Adenocarcinoma [TUMOR IMMUNOLOGY]
Key Points Expression of csMHCII is a determinant of the composition of the TME. csMHCII is a factor determining the response to anti–PD-1 therapy...
Learn moreEfficient CRISPR/Cas9 Gene Editing in Uncultured Naive Mouse T Cells for In Vivo Studies [NOVEL IMMUNOLOGICAL METHODS]
Key Points Cas9 RNP electroporation deletes genes in naive CD8+ T cells transferred in vivo. High efficiency gene deletion occurs even in the absence of T cell activation. Multiple gene KO and HDR edited cells can be generated using this...
Learn moreTranslating JAKs to Jakinibs [TRANSLATING IMMUNOLOGY]
The discovery of JAKs and STATs and their roles in cytokine and IFN action represented a significant basic advance and a new paradigm in cell signaling. This was quickly followed by discoveries pointing to their essential functions, including...
Learn moreThe Possible Uses and Challenges of Nanomaterials in Mast Cell Research [BRIEF REVIEWS]
Mast cells are tissue-resident immune cells that are involved in inflammation and fibrosis but also serve beneficial roles, including tissue maintenance, angiogenesis, pathogen clearance, and immunoregulation. Their multifaceted response and the...
Learn moreInduction of I{kappa}B{zeta} Augments Cytokine and Chemokine Production by IL-33 in Mast Cells [ALLERGY AND OTHER HYPERSENSITIVITIES]
Key Points IL-33 promoted the rapid and robust induction of IB in mast cells. IB enhanced cytokine production to assist NF-B in IL-33/ST2L signaling...
Learn morePEPITEM/Cadherin 15 Axis Inhibits T Lymphocyte Infiltration and Glomerulonephritis in a Mouse Model of Systemic Lupus Erythematosus [AUTOIMMUNITY]
Key Points The PEPITEM/CDH15 axis is involved in homeostasis in pathological inflammation. PEPITEM could be used as a therapeutic agent for systemic lupus erythematosus...
Learn moreTreating Autoimmune Diseases by Targeting IL-23 with Gene-Silencing Pyrrole-Imidazole Polyamide [AUTOIMMUNITY]
Key Points Polyamide targeting IL-23 specifically inhibits the expression of IL-23. Polyamide targeting IL-23 is effective in treating psoriasis and EAU in mice...
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