miR-155 in T cells contributes to the shortened lifespan of miR-146a–/– mice.
Autoimmunity in aged miR-146a–/– mice is mediated in part by T cell miR-155.
Aerobic glycolysis is associated with increased...
HuR regulates Th17 cell and Th1-like Th17 cell differentiation.
HuR directly and indirectly modulates expression of RUNX1 and RORt, respectively.
Targeting HuR by its inhibitor reduces severity of autoimmune neuroinflammation...
Free ISG15 causes tissue alert in the skin upon therapeutic vaccination in mice.
Free ISG15 is a potent adjuvant for the CTL response, acting, in part, via NK cells.
Free ISG15 function in mice requires amino acids defining...
SCFβ-TrCP E3 ubiquitin ligase governs TIPE2 protein stability.
TAK1 phosphorylates Ser3 to trigger TIPE2 for ubiquitination and degradation.
The amount of TIPE2 determines the strength of LPS-induced signaling...
TLR stimulation of B cells into Ig-secreting plasma cells requires NOX-dependent ROS.
The high secretion of IgG per cell results in excessive ROS-dependent ER stress.
NAC selectively inhibits the secretion of IgG and not that of...
The chromatin modifying BAP complex regulates Drosophila immune mechanisms.
Transcriptome analysis of osa RNAi flies indicates a role for Osa in metabolism.
Osa negatively regulates immunity and enhances expression of metabolic...
ADAR1 depletion from early developmental stages impairs T cell development in mice.
Concurrent MDA5 deletion partially ameliorates aberrant thymocyte development.
The RNA-editing–independent function of ADAR1 is required...
IL-10 antagonizes IL-17 in determining clinical disease phenotypes of periodontitis.
IL-10 dampens an IL-17–mediated inflammatory response in innate immune cells.
Bone loss in Il10–/– mice is associated with an...
Type I and III IFNs exacerbate pertussis lung inflammation in adult mice.
Infant mice do not upregulate IFN expression in response to pertussis.
Increased type I IFN signaling protects infant mice from pertussis lethality...