Open AccessEditorialFirst Online: 17 August 2017Received: 26 May 2017Accepted: 01 August 2017Summary1. HRQoL assessment requires a rigorous scientific approach to determine factors affecting the burden of disease.2. The introduction and the...
Learn moreLong-Term Survival After Hematopoietic Stem Cell Transplantation for Complete STAT1 Deficiency
Abstract Purpose Complete signal transducer and activator of transcription 1 (STAT1) deficiency is a rare autosomal recessive condition characterized by impairment of intracellular signaling from both type I and type II interferons (IFN)...
Learn morePoor sleep is highly associated with house dust mite allergic rhinitis in adults and children
Abstract Background Sleep disorders are often underreported to physicians by patients with allergies. This study aimed to characterize the sleep disorders associated with respiratory allergy to house dust mites (HDM) at the time of initiation...
Learn moreBialellic Mutations in Tetratricopeptide Repeat Domain 7A ( TTC7A ) Cause Common Variable Immunodeficiency-Like Phenotype with Enteropathy
Fig E2Ribbon structure model of TTC7A and tetratricopeptide repeat domains. All known pathogenic variants in apoptotic enterocolitis, multiple intestinal atresias, combined immunodeficiency, and enteropathy-lymphocytopenia-alopecia are mapped...
Learn moreGastrointestinal Manifestations of STAT3-Deficient Hyper-IgE Syndrome
Abstract Objective STAT 3 deficiency (autosomal dominant hyper immunoglobulin E syndrome (AD-HIES)) is a primary immunodeficiency disorder with multi-organ involvement caused by dominant negative signal transducer and activator of...
Learn moreProtective barrier properties of Rhinosectan ® spray (containing xyloglucan) on an organotypic 3D airway tissue model (MucilAir): results of an in vitro study
Abstract Background To evaluate barrier protective properties of Rhinosectan® spray, a medical device containing xyloglucan, on nasal epithelial cells (MucilAir). Methods MucilAir-Nasal, a three-dimensional organotypic (with different...
Learn moreImmunomodulatory Molecule IRAK-M Balances Macrophage Polarization and Determines Macrophage Responses during Renal Fibrosis [INNATE IMMUNITY AND INFLAMMATION]
Activation of various innate immune receptors results in IL-1 receptor–associated kinase (IRAK)-1/IRAK-4–mediated signaling and secretion of proinflammatory cytokines such as IL-12, IL-6, or TNF-α, all of which are implicated in...
Learn moreLung Epithelial Cell-Derived Microvesicles Regulate Macrophage Migration via MicroRNA-17/221-Induced Integrin {beta}1 Recycling [INNATE IMMUNITY AND INFLAMMATION]
Robust lung inflammation is one of the prominent features in the pathogenesis of acute lung injury (ALI). Macrophage migration and recruitment are often seen at the early stage of lung inflammatory responses to noxious stimuli. Using an acid...
Learn moreN-Arachidonoyl Dopamine Modulates Acute Systemic Inflammation via Nonhematopoietic TRPV1 [INNATE IMMUNITY AND INFLAMMATION]
N-Arachidonoyl dopamine (NADA) is an endogenous lipid that potently activates the transient receptor potential vanilloid 1 (TRPV1), which mediates pain and thermosensation. NADA is also an agonist of cannabinoid receptors 1 and 2. We have...
Learn moreA Systems Vaccinology Approach Reveals Temporal Transcriptomic Changes of Immune Responses to the Yellow Fever 17D Vaccine [SYSTEMS IMMUNOLOGY]
In this study, we used a systems vaccinology approach to identify temporal changes in immune response signatures to the yellow fever (YF)-17D vaccine, with the aim of comprehensively characterizing immune responses associated with protective...
Learn moreAn Unbiased Linkage Approach Reveals That the p53 Pathway Is Coupled to NK Cell Maturation [SYSTEMS IMMUNOLOGY]
Natural killer cells constitute potent innate lymphoid cells that play a major role in both tumor immunosurveillance and viral clearance via their effector functions. A four-stage model of NK cell functional maturation has been established...
Learn moreRegulated Polarization of Tumor-Associated Macrophages by miR-145 via Colorectal Cancer-Derived Extracellular Vesicles [TUMOR IMMUNOLOGY]
Macrophages are polarized into functional classically activated and alternatively activated (M2) phenotypes depending on their microenvironment, and these cells play an important role in the immune system. M2-like polarization of tumor-associated...
Learn more