3.Shearer WT, Rosenblatt HM, Gelman RS, Oyomopito R, Plaeger S, Stiehm ER, et al. Lymphocyte subsets in healthy children from birth through 18 years of age: the Pediatric AIDS Clinical Trials Group P1009 study. J Allergy Clin Immunol...
Learn moreIFNɣ Block, Treosulfan Conditioning and αβ T Cell Deplete PBSCT for XIAP-Deficient HLH
6.Marsh RA, Vaughn G, Kim MO, Li D, Jodele S, Joshi S, et al. Reduced-intensity conditioning significantly improves survival of patients with hemophagocytic lymphohistiocytosis undergoing allogeneic hematopoietic cell transplantation. Blood...
Learn moreA Novel {alpha}9 Integrin Ligand, XCL1/Lymphotactin, Is Involved in the Development of Murine Models of Autoimmune Diseases [AUTOIMMUNITY]
The integrin α9β1 is a key receptor involved in the development of autoimmune diseases. However, the detailed mechanism for the association of α9β1 integrin with its ligands remains unclear. In this study, we introduce...
Learn moreAntigen-Specific T Cell Analysis Reveals That Active Immune Responses to {beta} Cell Antigens Are Focused on a Unique Set of Epitopes [AUTOIMMUNITY]
CD38 is an activation marker that is present on recently activated T cells, but absent on resting memory T cells. In this study, we show that CD45RO+CD38+ β cell Ag-specific CD4+ T cells were present at higher frequencies in type 1 diabetes...
Learn moreControlled Human Malaria Infection Leads to Long-Lasting Changes in Innate and Innate-like Lymphocyte Populations [CLINICAL AND HUMAN IMMUNOLOGY]
Animal model studies highlight the role of innate-like lymphocyte populations in the early inflammatory response and subsequent parasite control following Plasmodium infection. IFN- production by these lymphocytes likely plays a key role in the...
Learn moreViral RNA-Unprimed Rig-I Restrains Stat3 Activation in the Modulation of Regulatory T Cell/Th17 Cell Balance [IMMUNE REGULATION]
Innate immunity activation by viral RNA–primed retinoid acid inducible gene-I (Rig-I) in CD4+ T cells antagonizes TGFβ signaling to suppress the differentiation of regulatory T cells (Tregs). However, how viral RNA–unliganded...
Learn moreT Cells Deficient in the Tyrosine Phosphatase SHP-1 Resist Suppression by Regulatory T Cells [IMMUNE REGULATION]
The balance between activation of T cells and their suppression by regulatory T cells (Tregs) is dysregulated in autoimmune diseases and cancer. Autoimmune diseases feature T cells that are resistant to suppression by Tregs, whereas in cancer, T...
Learn morePhysiologic Thymic Involution Underlies Age-Dependent Accumulation of Senescence-Associated CD4+ T Cells [IMMUNE REGULATION]
Immune aging may underlie various aging-related disorders, including diminished resistance to infection, chronic inflammatory disorders, and autoimmunity. PD-1+ and CD153+ CD44high CD4+ T cells with features of cellular senescence, termed...
Learn moreSOCS1 Is a Key Molecule That Prevents Regulatory T Cell Plasticity under Inflammatory Conditions [IMMUNE REGULATION]
We previously showed that regulatory T cells (Tregs) from T cell–specific Socs1-deficient mice (Socs1fl/flLck-Cre+ mice) easily convert into Th1- or Th17-like cells (ex-Tregs), which lose Foxp3 expression and suppressive functions in vivo...
Learn moreCritical Role of P2Y12 Receptor in Regulation of Th17 Differentiation and Experimental Autoimmune Encephalomyelitis Pathogenesis [AUTOIMMUNITY]
Adenosine 5′-diphosphate is a key endogenous cell-signaling molecule that can activate P2 purinergic receptor family members. ADP-P2Y signaling is reported to be associated with inflammation, but its function in T cell differentiation and...
Learn moreOccludin Expression in Epidermal {gamma}{delta} T Cells in Response to Epidermal Stress Causes Them To Migrate into Draining Lymph Nodes [ALLERGY AND OTHER HYPERSENSITIVITIES]
Epidermal T cells that reside in the front line of the skin play a pivotal role in stress immune surveillance. However, it is not clear whether these cells are involved in further induction of immune responses after they are activated in...
Learn moreAirway Epithelial Cells Are Crucial Targets of Glucocorticoids in a Mouse Model of Allergic Asthma [ALLERGY AND OTHER HYPERSENSITIVITIES]
Although glucocorticoids (GCs) are a mainstay in the clinical management of asthma, the target cells that mediate their therapeutic effects are unknown. Contrary to our expectation, we found that GC receptor (GR) expression in immune cells was...
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