Phenotypification on a common variable immunodeficiency population in a third level center

Authors: César Fidel Nogueda García(1), Patricia María O´Farrill Romanillos (1)
(1) Instituto Mexicano del Seguro Social, México City, México
Introduction: the main goal of phenotypifiyng the common variable immunodeficiency patients is to find the variable clinical presentations, and find out that patients who have a greater risk of malignancy, infectious complicaciones or autoimmunity. Method: On 35 patients with common variable immunodeficiency confirmed diagnosis, we classificated them using the Freiburg based on B memory cells clasification , every patient blood sample was analyzed by immunophenotyping by flow citometry and compared each patient acording the clinical chapel phenotypes. Results: we identified on 35 patients, 13 male ( 37.1%) and 22 female (62.8%), and acording the Freiburg phenotype and findings on de immunophenotype study we identified 11 patients with the 1A phenotype (31.4%), 13 patients with the 1B phenotype (37.1%) and 11 patients with the 2 phenotype (31.4%). 1A phenotype patients, in 8 (72%) were identified autoimmunity, in 2 (18.1%) lymphocitic infiltration, in 8 (72%) infections in 8 (72%) structural damage. 1B phenotype patients, in 8 (61.5%) were identified autoimmunity, in 3 (23%) lymphocitic infiltration, in 10 (76.9%) infections in 10 (76.9%) structural damage. 2 phenotype patients, in 6 (54%) were identified autoimmunity, in 2 (18.%%) lymphocitic infiltration, in 7 (63.6%) infections in 10 (76.9%) structural damage. We found that the highest rate of autoimmunity its in the 1A phenotype, the lymphocitic infiltration was more frequent in the 1B phenotype, the infection rate was higher in the 1B phenotype and the structural damage was more frequent in the 1B phenotype.
Conclusions: classification on phenotypes will allow to reach a better follow up of these patients , and identify patients which hace greater risk to develop complications.
Corresponding author: César Fidel Nogueda García
E-mail: [email protected]
Phone Number: 7444001965
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