ORP5L extracts and presents PIP2 to PLC1 for hydrolysis in the plasma membrane.
ORP5L maintains IP3/Ca2+ signaling in T cells.
ORP5L facilitates T cell proliferation via Ca2+-/NFAT-dependent pathway...
RAB7 small GTPase colocalizes with engaged receptors on mature endosomes in B cells.
RAB7 directly interacts with TRAF6 to transduce receptor signals in NF-B activation.
RAB7 overexpression in normal and lupus B cells enhances...
Galectin-9 is abundantly expressed in the cytosol of T cells.
Intracellular galectin-9 potentiates proximal TCR signaling.
Galectin-9 in T cells positively modulates the pathogenesis of autoimmune diseases...
VCAM1 is heterogeneously expressed in endothelial cells after TNF-α induction.
Heterogeneous VCAM1 promoter DNA methylation is mitotically heritable.
Heterogeneity in cytokine responsiveness occurs in many endothelial...
Methadone use alters circulating CD8+ T cell subsets, decreasing TEMRA cell frequency.
Expression of the opioid receptors and TCRs is not modulated by methadone use.
Ex vivo stimulation of μ-OR or -OR produces distinct surface...
CXCR4a and CXCR4b prefer to bind LPS and SDF-1 in teleosts, respectively.
CXCR4b inhibits HSPC proliferation in ayu by regulating ROS levels.
CXCR4a+ HSPCs are prone to differentiate into myeloid cells in ayu...
Gut bacteria–associated sepsis in irradiated mice was controlled by GL.
This compound inhibited M2bM polarization at the bacteria translocation site.
Expression of Gas5 (down) and miR-222 (up) in M was improved by GL...
B. anthracis PGA elicits fewer cytokines in smaller amounts than B. subtilis PGA and B. licheniformis PGA.
B. anthracis PGA is recognized less effectively by human TLRs 2 and 4.
B. anthracis PGA is more resistant to human...
Helminth infections alter monocyte activation and function in latent TB.
Helminth infections also alter T cell activation in latent TB.
These alterations are for the most part reversed by anthelmintic chemotherapy...