Tuning Macrophage Phenotype to Mitigate Skeletal Muscle Fibrosis [INNATE IMMUNITY AND INFLAMMATION]
IRCTX muscle injury results in muscle fibrosis through macrophage-derived TGF-β1.
FAPs respond to TGF-β1 by differentiating into fibroblasts.
Conditional knockout and systemic inhibition of TGF-β1 attenuates IRCTX fibrosis.