Leukemia Inhibitory Factor Inhibits Plasmacytoid Dendritic Cell Function and Development [INNATE IMMUNITY AND INFLAMMATION]
pDCs express LIFR.
LIF inhibits pDC production of type I IFN.
LIF biases DC development towards cDCs at the expense of pDCs.
The Journal of Immunology
Negative Regulation of TLR Signaling by BCAP Requires Dimerization of Its DBB Domain [MOLECULAR AND STRUCTURAL IMMUNOLOGY]
Dimerization of the BCAP Toll/IL1 domain is required for function.
BCAP TIR modulates the oligomerization state of TLR signaling adaptor MAL.
TIG domains are a promiscuous dimerization module in gene expression and signaling.
Gut Microbiota Contributes to Spontaneous Colitis in E3 Ligase Itch-Deficient Mice [MUCOSAL IMMUNOLOGY]
Spontaneous colitis in Itch-deficient mice is associated with altered gut microbiota.
Alterations in gut microbiota are independent of elevated IL-17 in Itch-deficient mice.
Bacteroides vulgatus induces colonic inflammation in Itch–/– mice.
Neutrophil Extracellular Trap-Associated CEACAM1 as a Putative Therapeutic Target to Prevent Metastatic Progression of Colon Carcinoma [TUMOR IMMUNOLOGY]
CEACAM1 is an essential contributor in the NET–tumor cell interaction.
CEACAM1 is a potential target for preventing liver metastasis of colon cancer.
Cancer Cell-Intrinsic Expression of MHC Class II Regulates the Immune Microenvironment and Response to Anti-PD-1 Therapy in Lung Adenocarcinoma [TUMOR IMMUNOLOGY]
Expression of csMHCII is a determinant of the composition of the TME.
csMHCII is a factor determining the response to anti–PD-1 therapy.
Efficient CRISPR/Cas9 Gene Editing in Uncultured Naive Mouse T Cells for In Vivo Studies [NOVEL IMMUNOLOGICAL METHODS]
Cas9 RNP electroporation deletes genes in naive CD8+ T cells transferred in vivo.
High efficiency gene deletion occurs even in the absence of T cell activation.
Multiple gene KO and HDR edited cells can be generated using this method.
Tuning Macrophage Phenotype to Mitigate Skeletal Muscle Fibrosis [INNATE IMMUNITY AND INFLAMMATION]
IRCTX muscle injury results in muscle fibrosis through macrophage-derived TGF-β1.
FAPs respond to TGF-β1 by differentiating into fibroblasts.
Conditional knockout and systemic inhibition of TGF-β1 attenuates IRCTX fibrosis.
NOD1 Promotes Antiviral Signaling by Binding Viral RNA and Regulating the Interaction of MDA5 and MAVS [INNATE IMMUNITY AND INFLAMMATION]
NOD1 restricts replication of RNA viruses.
The cumulative effects between NOD1 and MDA5 normal form are conserved.
NOD1 degradation by the truncated form of MDA5 is specific to fish.
Zhx2 Accelerates Sepsis by Promoting Macrophage Glycolysis via Pfkfb3 [INNATE IMMUNITY AND INFLAMMATION]
Zhx2 in macrophages accelerates sepsis.
Zhx2 promotes glycolysis in macrophages via Pfkfb3.
An Essential Role for Perforin-2 in Type I IFN Signaling [INNATE IMMUNITY AND INFLAMMATION]
Type I IFN–mediated JAK–STAT signaling is impaired in Perforin-2–deficient cells.
Perforin-2 independently associates with IFNAR1 and IFNAR2 in resting cells.
Perforin-2 is critical for the activation of Jak1 and Tyk2 upon IFN-β stimulation.