Type I IFN–mediated JAK–STAT signaling is impaired in Perforin-2–deficient cells.
Perforin-2 independently associates with IFNAR1 and IFNAR2 in resting cells.
Perforin-2 is critical for the activation of Jak1...
Dimerization of the BCAP Toll/IL1 domain is required for function.
BCAP TIR modulates the oligomerization state of TLR signaling adaptor MAL.
TIG domains are a promiscuous dimerization module in gene expression and signaling...
Spontaneous colitis in Itch-deficient mice is associated with altered gut microbiota.
Alterations in gut microbiota are independent of elevated IL-17 in Itch-deficient mice.
Bacteroides vulgatus induces colonic inflammation in...
Cas9 RNP electroporation deletes genes in naive CD8+ T cells transferred in vivo.
High efficiency gene deletion occurs even in the absence of T cell activation.
Multiple gene KO and HDR edited cells can be generated using this...
IRCTX muscle injury results in muscle fibrosis through macrophage-derived TGF-β1.
FAPs respond to TGF-β1 by differentiating into fibroblasts.
Conditional knockout and systemic inhibition of TGF-β1 attenuates IRCTX...