Mycobacterium tuberculosis-Induced Bronchoalveolar Lavage Gene Expression Signature in Latent Tuberculosis Infection Is Dominated by Pleiotropic Effects of CD4+ T Cell-Dependent IFN-{gamma} Production despite the Presence of Polyfunctional T Cells within the Airways [INFECTIOUS DISEASE AND HOST RESPONSE]

Key Points IFN- dominates the CD4+-dependent M. tuberculosis–induced BAL cell gene signature in LTBI. Nevertheless, CD4+ BAL cells in LTBI display polyfunctional responses to M. tuberculosis. This signature may provide a means to...

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Terminal Effector CD8 T Cells Defined by an IKZF2+IL-7R- Transcriptional Signature Express Fc{gamma}RIIIA, Expand in HIV Infection, and Mediate Potent HIV-Specific Antibody-Dependent Cellular Cytotoxicity [INFECTIOUS DISEASE AND HOST RESPONSE]

Key Points Chronic HIV-1 is associated with increased levels of FcRIIIA+ CD8 T cells. FcRIIIA+ CD8 T cells display an innate transcriptomic profile akin to NK cells. ADCC is mediated by FcRIIIA+ CD8 T cells at levels comparable with NK...

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