PGRN decreases postinfluenza susceptibility to S. pneumoniae coinfection in mice.
PGRN increases survival of mice in lethal influenza/S. pneumoniae coinfection.
PGRN suppresses lung inflammation and ERS-mediated apoptosis in...
IFN- dominates the CD4+-dependent M. tuberculosis–induced BAL cell gene signature in LTBI.
Nevertheless, CD4+ BAL cells in LTBI display polyfunctional responses to M. tuberculosis.
This signature may provide a means to...
Chronic HIV-1 is associated with increased levels of FcRIIIA+ CD8 T cells.
FcRIIIA+ CD8 T cells display an innate transcriptomic profile akin to NK cells.
ADCC is mediated by FcRIIIA+ CD8 T cells at levels comparable with NK...
This study identified two distinct alveolar macrophage populations in old mice.
A CD11c+ CD11b– alveolar macrophage population is immune regulatory.
CD11c+ CD11b+ macrophages are more inflammatory and permissive for M...
IL-37 is expressed in alveolar epithelial cells and macrophages.
IL-37 levels are decreased in lung and blood obtained from IPF patients.
IL-37 attenuates lung fibrosis by inducing autophagy and inhibiting TGF-β1...
LL-37 antimicrobial peptides promote macrophage uptake of NETs.
NETs modulate LPS-induced cytokine responses in macrophages and DCs.
NETs are digested intra- and extracellularly by TREX1 and DNase1L3...
MK2/3 are the only LPS-induced kinases for S52 and S178 of TTP.
TNF regulation by MK2/3 is not restricted to TTP phosphorylation at S52 and S178.
The MK2/3/TTP signaling axis contributes to sepsis in vivo...
Oral H1-antihistamines (AHs) are the most commonly used therapy to treat allergic rhinitis and chronic urticaria. Older, first-generation AHs (e.g. diphenhydramine, hydroxyzine) have significant and common side effects including...