A Severe Anaphylactic Reaction Associated with IgM-Class Anti-Human IgG Antibodies in a Hyper-IgM Syndrome Type 2 Patient


This work was supported in part by the Ministry of Defense, Japan; the Research on Measures for Intractable Diseases Project (H29-013, H26-037, H23-012): matching fund subsidy from the Ministry of Health, Labour and Welfare, Japan; the Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan (17913039, 26293250, 15 K09640); the Practical Research for Rare/Intractable Diseases from Japan Agency for Medical Research and Development, AMED; the Japan Foundation for Pediatric Research; the Jeffrey Modell Foundation; and the Kawano Masanori Memorial Public Interest Incorporated Foundation for Promotion of Pediatrics.

Authors’ Contributions

KI and SN contributed to study conception and design; YT wrote the manuscript and SN and KI reviewed the manuscript; KH performed the ELISA to detect the IgM-type anti IgG antibody; YT preformed the ELISA to detect the IgM-type anti-IgA, IgM-type anti-IgM, IgM-type anti-BSA, IgE-type anti-IgG, and IgA antibody; TH designed assays to measure C3a and C5a and YT performed those assays; KI, KH, CK, and SN contributed to interpretation of data; YT performed the statistical analysis; SN provided clinical samples and data; and all authors reviewed the manuscript and approved the final version.

Compliance with Ethical Standards

The experiments in this study were done after written informed consent had been obtained and according to the permits issued by the Institutional Review Board of National Defense Medical College (permit number 1275).

Research Involving Human Participants

All procedures performed in the study were in accordance with the Helsinki principles, and the study was approved by the Institutional Review Board of the National Defense Medical College.

Conflict of Interest

The authors declare that they have no conflicts of interest.

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